Absolutely you can enrol in commercial pilot lessons even if you haven't flown before. These lessons are designed to take you from zero experience to a professional level. For example on the course page for Pilot CET it explains that learners will undertake both ground classes and practical flying under guidance of an expert instructor. What this means is: you don't need to have already flown an airplane. The training starts with building your knowledge base (air regulations meteorology navigation aircraft systems) and supervised flights so you learn step by step.
When you begin commercial pilot lessons you'll typically start with ground training learning theory such as aircraft technical knowledge flight planning meteorology communication and navigation. Then you'll move into dual flights (with an instructor) to get hands on experience take offs landings cross country flying night flying instrument flying. Only after you build confidence and skill will you progress to solo flights (still within the training regimen). So even with no prior flying, the curriculum is structured to bring you up to speed.
Even though you don't need flying experience there are basic eligibility criteria you must satisfy before/while you begin commercial pilot lessons:
Minimum age: Usually around 17-18 years before licence issue (some training can start at 17) in India.
Education: Generally 10+2 (or equivalent) with Physics and Mathematics from a recognised board.
Medical fitness: You'll need to pass a Class 1 medical exam (in India under Directorate General of Civil Aviation DGCA) showing that your vision hearing and general health meet aviation standards.
English proficiency: Since aviation communication and regulation are globally English based you'll need to be able to read/write and speak English to a required standard.
If you meet these eligibility conditions then your lack of prior flying experience is not a barrier.
Training programmes for commercial pilot lessons are built with the assumption that many students come in with little or no flight time. The idea is that the flying school guides you from ground theory supervised flying solo flying final exams and licence. So you're not expected to already know how to fly. Additionally the course referenced by Pilot CET emphasises this by saying their commercial pilot lessons prepare students to handle real world flight operations with confidence and build flying skills & safety even for those starting fresh.
Choose a flying academy that is approved by the regulatory body (in India, the DGCA).
Clarify how many flying hours are included and what type of aircraft you'll train on (the quality matters).
Understand the cost upfront - training is a major investment. For example in India the fees for commercial pilot lessons may be in the range of INR 45-55 lakhs including flying hours.
Start early with medical check and registration because these can take time. If your health criteria are not clear you can face delays.
If you don't have a science (Physics & Math) background check if the institute offers bridging or remedial sessions some rule changes are underway regarding stream flexibility.
Maintain readiness: flying weather aircraft availability and your progress affect the duration of the programme.